PE Anti-Mouse CD123 Antibody[5B11]
Produktgrößen
50 tests
£74,00
AN00962D-50TESTS
100 tests
£93,00
AN00962D-100TESTS
2 x 100 tests
£127,00
AN00962D-2X100TESTS
Über dieses Produkt
- SKU:
- AN00962D
- Zusätzliche Namen:
- IL-3 Receptor A Alpha chain,IL-3RA Alpha
- Anwendung:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 5B11
- Klonalität:
- Monoclonal
- Konjugat:
- R-PE
- Weitere Details:
- CD123 is a 70 kD A Alpha chain subunit of the IL-3 receptor (IL-3R A Alpha). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common B Beta chain (CDw131) or the IL-3R B Beta chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the A Alpha subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R B Beta subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
- Host:
- Rat
- Immunogen:
- CD123
- Isotyp:
- IgG2a
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:WqwE9QG3