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Antikörper

AF/LE Purified Anti-Mouse CD152 Antibody[9D9]

Produktgrößen
25 ug
£66,00
AN008120-25UG
100 ug
£89,00
AN008120-100UG
1 mg
£171,00
AN008120-1MG
5 mg
£490,00
AN008120-5MG
25 mg
£1515,00
AN008120-25MG
50 mg
£2247,00
AN008120-50MG
100 mg
£3211,00
AN008120-100MG
Über dieses Produkt
SKU:
AN008120
Zusätzliche Namen:
GRD;Cytotoxic T-lymphocyte protein;Cytotoxic T-lymphocyte-associated antigen;IDDM;CELIAC;CELIAC3;CTLA-4;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;GRD4;GSE;IDDM12;Cd152;Ctla4; Ly-56;Ctla4;Ly-56
Anwendung:
Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
9D9
Klonalität:
Monoclonal
Konzentration:
>= 1 mg/ml
Weitere Details:
CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on Human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied.
Host:
Mouse
Immunogen:
CD152|Recombinant Human CD152 protein
Isotyp:
IgG2b, kappa
Reinheit:
>98%
Aufreinigung:
protein a/g purified
Reaktivitäten:
Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
Human peripheral blood platelet were stained with 0.2 ug Purified Anti-Human CD61 Antibody[VI-PL2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug AF/LE Purified Anti-Human CD95 Antibody[DX2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-17A gene were stained with 0.2 ug Purified Anti-Human IL-17A Antibody[BL168] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
HEL were stained with 0.2 ug Purified Anti-Human CD90 Antibody[5E10] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood platelet were stained with 0.2 ug Purified Anti-Human CD61 Antibody[VI-PL2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.