IL-17C Polyclonal Antibody
Produktgrößen
25 ul
£134,00
AN006890L-25UL
100 ul
£291,00
AN006890L-100UL
Über dieses Produkt
- SKU:
- AN006890L
- Zusätzliche Namen:
- IL17C;CX2;IL-17C;Cytokine CX2;IL 17C;IL 21;Interleukin 17C;Interleukin-17C
- Anwendung:
- Western Blot
- Buffer:
- PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported. Mouse IL-17C cDNA encodes a 194 amino acid (aa) protein with a putative 14 aa signal peptide. Although there are no potential N-linked glycosylation sites, it is reportedly glycosylated. IL-17C shares from 15%-30% aa sequence identity with other IL-17 family members. Mouse and human IL-17C share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) in an adult prostate and fetal kidney libraries. IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B. Human IL-17C is active on mouse cells.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse IL-17C protein expressed by E.coli
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-il_17c_polyclonal_antibody-an006890l