DPP4/CD26 Polyclonal Antibody
Produktgrößen
25 ul
£134,00
AN006840L-25UL
100 ul
£291,00
AN006840L-100UL
Über dieses Produkt
- SKU:
- AN006840L
- Zusätzliche Namen:
- DPP;Adenosine Deaminase Complexing Protein;ADCP;ADABP;ADCP2;Adenosine Deaminase Complexing Protein 2;DPPIV;TP103;Cd26;Dpp4;Dipeptidyl peptidase IV (DPP IV); THAM
- Anwendung:
- Western Blot
- Buffer:
- PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse DPP4/CD26 protein expressed by Mammalian
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:cd26_polyclonal_antibody-an006840l