TNF RI/TNFRSF1A Polyclonal Antibody
Produktgrößen
25 ul
£134,00
AN005930L-25UL
100 ul
£291,00
AN005930L-100UL
Über dieses Produkt
- SKU:
- AN005930L
- Zusätzliche Namen:
- CD120a,FPF,MS5,p55-R,p60,TBP1,TNFAR,TNFR1,TNFR1-d2,TNFR55,TNF-R55,TNFR60,TNF-R-I,TBP,TNFalpha-R,TNF-alphaR,TNFRp,TNFR1-d,FPF,MS5,p55,p55-R,p60,TBP1,TNFalpha-R1,TNF-alphaR1,TNFAR,Tnfr,TNF-R,TNF-R1,TNFR1-d2,TNFR55,TNF-R55,TNFR60,TNFRI,TNF-R-I,TNFRp55,Tnfr-1,Tnfr1,Tnfrsf1a,CD120a,TNFR-I, p55, TNFRSF1a
- Anwendung:
- Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- TNF-A Alpha is an important cytokine produced by numerous cell types, including neutrophils, activated lymphocytes, macrophages, and NK cells. It plays a critical role in inflammatory responses and apoptosis. TNF-A Alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-A Alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-A Alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders. The two receptors for TNF-A Alpha, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act through TNF-R1. Cytotoxicity is mediated by a "death domain" with the intracellular region of the receptor that binds to the death domain adaptor protein TRADD and triggers the activation of caspases (8). Soluble forms of both receptors have also been characterized which can bind TNF-A Alpha and may play an important role in immune disorders.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse TNF RI/TNFRSF1A protein expressed by E.coli
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:tnfrsf1a_polyclonal_antibody-an005930l