PCNA Monoclonal Antibody
Produktgrößen
25 ul
£97,00
AN005350L-25UL
100 ul
£171,00
AN005350L-100UL
Über dieses Produkt
- SKU:
- AN005350L
- Zusätzliche Namen:
- Proliferating cell nuclear antigen,PCNA,Cyclin
- Anwendung:
- Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- translate.label.attr.clone:
- 9C6
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- Host:
- Mouse
- Immunogen:
- Recombinant human PCNA protein expressed by E.coli
- Isotyp:
- IgG2a
- Aufreinigung:
- Protein A/G Purification
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:p-pcna_monoclonal_antibody-an005350l