FITC Anti-Human CD156c(ADAM10) Antibody[11G2]
Produktgrößen
20 tests
£145,00
AN00355C-20TESTS
100 tests
£291,00
AN00355C-100TESTS
2 x 100 tests
£484,00
AN00355C-2X100TESTS
Über dieses Produkt
- SKU:
- AN00355C
- Zusätzliche Namen:
- MADM;KUZ;alpha-secretase
- Anwendung:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 11G2
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Konzentration:
- 5 ul/test
- Weitere Details:
- CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-A Alpha, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.
- Host:
- Mouse
- Immunogen:
- CD156c
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:p-fitc_anti_human_cd156c(adam10)_antibody[11g2]-an00355c