PI(3,5)P2 diC8
Produktgrößen
100 ug
£196,00
ECH-P-3508-100UG
500 ug
£476,00
ECH-P-3508-500UG
1 mg
£757,00
ECH-P-3508-1MG
Über dieses Produkt
- SKU:
- ECH-P-3508
- Weitere Details:
- PI(3,5)P2 diC8 (Phosphatidylinositol 3,5-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,5)P2. \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). \n \n \n \nFeatured in Publications \n1. Marcus, S. L., M. R. Wenk, et al. (2001). "A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation." FEBS Lett 494(3): 201-7 \n2. Johnson, L. M., K. M. James, et al. (2005). "Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity." Biochemistry 44(9): 3432-3440. \n3. Ikonomov, O. C., D. Sbrissa, et al. (2009). "Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes." J Biol Chem 284(36): 23961-71. \n4. Silswal, N., et al. (2011). "Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction." Am J Physiol Heart Circ Physiol 300(6): H2016-2026. \n5. Kirsch, S. A., et al. (2018). "Phosphatidylinositol-3, 5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2." Cellular and Molecular Life Sciences: 1-13. \n \nProduct Keywords: Dioctanoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 (8:0/8:0), PI(3,5)P2 C8 \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Echelon Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
