[4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)
Produktgrößen
1 mg
£141,00
ECH-L-3223-1MG
5 mg
£368,00
ECH-L-3223-5MG
10 mg
£594,00
ECH-L-3223-10MG
Über dieses Produkt
- SKU:
- ECH-L-3223
- Weitere Details:
- L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-B Beta levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2). \n \n \n \nStorage \n-20°C or below. \nFeatured in Publications \n1) Tager, A.M. (2012) "Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis" Am. J. Resp. Cell Mol. Biol. 47(5): 563-565. \n2) Oikonomou, N, M.A. Mouratis, et al. (2012) "Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis." Am. J. Resp. Cell Mol. Biol. 47(5): 566-574. \n3) Jiang, G., D. Madan, et al. (2011). "Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin." Bioorganic & Medicinal Chemistry Letters 21(17): 5098. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Echelon Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
