KP372-1 (Akt Inhibitor)
Produktgrößen
5 mg
£497,00
ECH-B-0102-5MG
Über dieses Produkt
- SKU:
- ECH-B-0102
- Weitere Details:
- KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. Provided as a 1:1 mixture of regioisomers. \n \n \n \nSolubility \nWater: insoluble, DMSO: 5 mg/mL \nStorage \n2-8oC. Stock solutions should be stored frozen (-20oC). \nReferences \n1) M. Mandal et al. "The Akt Inhibitor KP372-1 Suppresses Akt Activity and Cell Proliferation and Induces \nApoptosis in Thyroid Cancer Cells" Br. J. Cancer, 2005, 92, 1899-1905. \n2) Z. Zeng et al "Simultaneous Inhibition of \nPDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial \nDysfunction and Apoptosis in Acute Myelogenous Leukemia." Cancer Res., 2006, 66, 3737-3746. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Echelon Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
