Caspase 8 Substrate, colorimetric
Produktgrößen
5 mg
£219,00
ECH-860-56-5MG
25 mg
£598,00
ECH-860-56-25MG
Über dieses Produkt
- SKU:
- ECH-860-56
- CAS Number:
- 219138-21-3
- Weitere Details:
- CAS Number: 219138-21-3 \nMolecular Weight: 638.26 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Ile-Glu-Thr-Asp-pNA \nSequence (1-letter): Ac-IETD-pNA \nStorage: -20 ?C or below \nSolubility: DMSO \n \nAc-IETD-pNA is a substrate for caspase-8 and granzyme B. Caspases are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Caspase-8 is an attractive therapeutic target for a variety of degenerative disorders. The absorbance maximum for the cleaved pNA is at 405 nm. \nReferences \n1. N.A.Thornberry et al., (1997) ?A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis? J. Biol. Chem. 272: 17907. \n2. Watt, W. et al. (1999) ?The atomic-resolution structure of human caspase-8, a key activator of apoptosis? Structure 7 (9): 1135?1143., Echelon
- Molekulargewicht:
- 638.26
- Sequenz:
- Ac-Ile-Glu-Thr-Asp-pNA \n
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Echelon Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Datenblatt des Herstellers:https://www.echelon-inc.com/product/ac-ile-glu-thr-asp-pna-caspase-8-granzyme-b/
