Spantide II
Produktgrößen
1 mg
£304,00
ECH-712-36-1MG
Über dieses Produkt
- SKU:
- ECH-712-36
- CAS Number:
- 129176-97-2
- Weitere Details:
- CAS Number: 129176-97-2 \nMolecular Weight: 1667.7 \nSalt Form: TFA \nPurity: >96% \nSequence (3-letter): e-nicotinoyl-D-Lys-Pro-3Pal-Pro-(3,4Cl)D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 (3Pal = 3-pyridylalanine) \nSequence (1-letter): (e-nicotinoyl)kP(3Pal)P((3,4Cl)D)FNwFwL(Nle)-NH2 \nStorage: -20 ?C or below \nSolubility: water (1 mg/mL) \n \nSpantide II is an undecapeptide substance P (SP) analog that is more potent as a substance P antagonist than spantide I and less effective in releasing histamine from mast cells. It is a neurokinin-1 receptor (NK-1R) antagonist that is used to control inflammation, particularly in skin conditions, and has negligible neurotoxicity. \nReferences \n1. Hakanson, R. et al. (1990) ?Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect? Regul. Pept. 31 (1): 75-82. \n2.Kincy-Cain, T. and Bost, K.L. (1996) ?Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II? J. Immunol. 157 (1): 255-264. \n3. Gerfen, C.R. (1991) ?Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain? Brain Res. 556 (1): 165?170., Echelon
- Molekulargewicht:
- 1667.7
- Sequenz:
- e-nicotinoyl-D-Lys-Pro-3Pal-Pro-(3,4Cl)D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 (3Pal = 3-pyridylalanine) \n
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Echelon Biosciences
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Datenblatt des Herstellers:https://www.echelon-inc.com/product/spantide-ii/