Recombinant Human IL-12
Produktgrößen
50ug
£468,00
Y04001-50UG
1mg
£2397,00
Y04001-1MG
Über dieses Produkt
- SKU:
- Y04001
- Anwendung:
- Bioactivity
- Weitere Details:
- IL-12 (Interleukin-12) is a key pro-inflammatory cytokine and a member of the IL-12 family, primarily produced by antigen-presenting cells such as dendritic cells, macrophages, and B cells. It is a heterodimeric protein (p70) composed of two subunits, p35 and p40, linked by a disulfide bond. IL-12 promotes Th1 cell differentiation by activating the STAT4 signaling pathway, driving the commitment of na?ve CD4+ T cells into Th1 cells and stimulating the secretion of pro-inflammatory cytokines such as IFN-γ. It also enhances the activity of NK and T cells by promoting the proliferation and cytotoxic function of NK cells and CTLs (cytotoxic T lymphocytes). Furthermore, IL-12 suppresses Th2 responses by inhibiting IL-4-mediated Th2 cell differentiation, thereby reinforcing cell-mediated immunity.
- Format:
- Lyophilized powder
- Formulierung:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% mannitol and 0.01% Tween 80, pH 7.4
- Host:
- Hamster
- Molekulargewicht:
- 59.0 kDa
- Reinheit:
- ≥95% by SDS-PAGE
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Hersteller:
- East-Mab Biomedical
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
