ES-2 Cells - Reproductive system cancer cell lines
Produktgrößen
1 each
£607,00
305038-1EACH
Über dieses Produkt
- SKU:
- 305038
- Zusätzliche Namen:
- ES2
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Weitere Details:
- The ES-2 cell line is derived from a poorly differentiated ovarian clear cell carcinoma, offering a unique in vitro model to study the biological behaviors and treatment responses of this aggressive cancer subtype. Originally cultured in soft agar, a method favoring the growth of cancer cells while suppressing fibroblast growth, ES-2 cells provide a robust system for analyzing tumor cell interactions and drug resistance mechanisms in a three-dimensional matrix that closely mimics the in vivo environment. Pharmacologically, ES-2 cells display low to moderate resistance to several chemotherapeutic agents, including doxorubicin, cisplatin, carmustine, etoposide, and cyanomorpholinodoxorubicin (MRA-CN). This resistance profile makes ES-2 an essential tool for oncology research, particularly in the development and testing of new chemotherapeutic regimens and combination therapies. Furthermore, the expression of P-glycoprotein in ES-2 cells is low, which is significant as P-glycoprotein is often implicated in the efflux of drugs from cancer cells, contributing to multidrug resistance. Studying ES-2 cells can therefore provide insights into overcoming drug resistance in ovarian clear cell carcinomas.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cytion
- Typ:
- Cells: Cell Lines
- Datenblatt des Herstellers:f619eceb097c4666abaaa3e6ff68dc94