NCI-H157 Cells - NCI cell lines | Lung cancer cell lines
Produktgrößen
1 each
£607,00
300387-1EACH
Über dieses Produkt
- SKU:
- 300387
- Zusätzliche Namen:
- NCI H157, H157, H-157, NCI-157
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Weitere Details:
- NCI-H157 is a human non-small cell lung carcinoma (NSCLC) cell line, primarily used in cancer research to study tumorigenesis, chemotherapy resistance, and the molecular pathways involved in lung cancer progression. NCI-H157 cells are particularly useful for investigating the role of hypoxia-inducible factor-1 alpha (HIF-1A Alpha) in NSCLC. Studies have shown that HIF-1A Alpha plays a crucial role in promoting angiogenesis, proliferation, and survival of cancer cells under hypoxic conditions. Downregulation of HIF-1A Alpha via siRNA in NCI-H157 cells significantly reduces cell proliferation, induces apoptosis, and impairs the invasive ability of the tumor cells. Moreover, combination treatments using HIF-1A Alpha siRNA and chemotherapy agents, such as cisplatin (DDP), enhance the cytotoxic effects on NCI-H157 cells. The reduction of HIF-1A Alpha expression has been shown to increase the activity of apoptotic proteins like caspases 3 and 9 while decreasing the levels of anti-apoptotic proteins such as Bcl-2. Additionally, HIF-1A Alpha knockdown inhibits key signaling pathways involved in tumor growth, including the PI3K/AKT and Raf/MEK/ERK pathways. These molecular alterations contribute to the suppression of tumor cell survival and invasiveness. The NCI-H157 cell line is also responsive to various natural compounds and plant extracts. For example, extracts from *Stellera chamaejasme* L. have been found to induce apoptosis in NCI-H157 cells through the Fas death receptor pathway, further emphasizing the cell line's utility in evaluating novel therapeutic agents for lung cancer.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cytion
- Typ:
- Cells: Cell Lines
- Datenblatt des Herstellers:2d2af9744f1a4e75ae2a16735b0259f5