KMS-12-BM Cells - Myeloma cell lines
Produktgrößen
1 each
£607,00
300287-1EACH
Über dieses Produkt
- SKU:
- 300287
- Zusätzliche Namen:
- KMS 12 BM, KMS-12BM, KMS12-BM, KMS12BM, KMS-12, KMS12, Kawasaki Medical School-12-Bone Marrow
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Weitere Details:
- The KMS-12-BM cell line is a human myeloma cell line established from the bone marrow of a patient with non-producing multiple myeloma. This cell line represents an immature plasmacytoid stage of B-cell differentiation, characterized by the expression of surface markers CD20, CD38, and PCA-1, but a lack of immunoglobulin production. The cells are notable for their distorted morphology, with many showing multinuclear and giant characteristics. Ultrastructurally, KMS-12-BM cells possess well-developed rough endoplasmic reticulum and ovoid eccentric nuclei with peripheral chromatin distribution, typical of plasmacytoid cells. KMS-12-BM cells exhibit a chromosomal abnormality, particularly a reciprocal translocation t(11;14)(q13;q32), which is often associated with multiple myeloma. These cells also display a broad range of chromosomal numbers, from hypodiploid to polyploid, indicating significant genomic instability. Unlike its counterpart KMS-12-PE, the KMS-12-BM line does not produce amylase, and it lacks immunoglobulin secretion or surface expression, making it suitable for studies involving immunoglobulin-nonproducing myeloma. Additionally, it shows low cloning efficiency in soft agar culture conditions, with less than 0.1% colony formation, and has no tumorigenic properties when injected into nude mice.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cytion
- Typ:
- Cells: Cell Lines
- Datenblatt des Herstellers:01920ea768157904b1cdcf6ffca8a503