JMY Antibody, Biotin conjugated
Produktgrößen
50 ug
£186,00
CSB-PA850838LD01HU-50UG
100 ug
£334,00
CSB-PA850838LD01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA850838LD01HU
- Zusätzliche Namen:
- FLJ37870 antibody; Jmy antibody; JMY protein antibody; JMY_HUMAN antibody; junction mediating and regulatory protein antibody; Junction mediating and regulatory protein p53 cofactor antibody; Junction-mediating and -regulatory protein antibody; MGC163496 antibody; OTTHUMP00000161976 antibody; WAS protein homology region 2 domain containing 1-like 3 antibody; WHDC1L3 antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- Biotin
- Weitere Details:
- Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Junction-mediating and -regulatory protein (708-848AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:JMY-Antibody-Biotin-conjugated-12782268.html