DDB2 Antibody, HRP conjugated
Produktgrößen
50 ug
£186,00
CSB-PA846067LB01HU-50UG
100 ug
£334,00
CSB-PA846067LB01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA846067LB01HU
- Zusätzliche Namen:
- damage-specific DNA binding protein 2 antibody; Damage-specific DNA-binding protein 2 antibody; DDB p48 subunit antibody; Ddb2 antibody; DDB2_HUMAN antibody; DDBb antibody; DNA damage-binding protein 2 antibody; UV-damaged DNA-binding protein 2 antibody; UV-DDB 2 antibody; Xeroderma pigmentosum group E protei antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DNA damage-binding protein 2 protein (1-185AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:DDB2-Antibody-HRP-conjugated-12782250.html