LAPTM4B Antibody, FITC conjugated
Produktgrößen
50 ug
£186,00
CSB-PA774814LC01HU-50UG
100 ug
£334,00
CSB-PA774814LC01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA774814LC01HU
- Zusätzliche Namen:
- LAPTM4B antibody; PSEC0001 antibody; Lysosomal-associated transmembrane protein 4B antibody; Lysosome-associated transmembrane protein 4-beta antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- FITC
- Weitere Details:
- Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:LAPTM4B-Antibody-FITC-conjugated-12784653.html