PARG Antibody, Biotin conjugated
Produktgrößen
50 ug
£186,00
CSB-PA773045LD01HU-50UG
100 ug
£334,00
CSB-PA773045LD01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA773045LD01HU
- Zusätzliche Namen:
- ADP riboseglycohydrolase antibody; Mitochondrial poly(ADP ribose) glycohydrolase antibody; Parg antibody; PARG_HUMAN antibody; PARG99 antibody; Poly antibody; poly (ADP ribose) glycohydrolase antibody; poly(ADP-ribose) glycohydrolase 60 kDa isoform antibody; Poly(ADP-ribose) glycohydrolase antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- Biotin
- Weitere Details:
- Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:PARG-AntibodyBiotin-conjugated-12552593.html