NHLRC1 Antibody
Produktgrößen
50 ul
£186,00
CSB-PA740936ESR2HU-50UL
100 ul
£334,00
CSB-PA740936ESR2HU-100UL
Über dieses Produkt
- SKU:
- CSB-PA740936ESR2HU
- Zusätzliche Namen:
- bA204B7.2 antibody; E3 ubiquitin-protein ligase NHLRC1 antibody; EPM2A antibody; EPM2B antibody; EPM2B gene antibody; Malin antibody; MGC119262 antibody; MGC119264 antibody; MGC119265 antibody; NHL repeat containing 1 antibody; NHL repeat containing E3 ubiquitin protein ligase 1 antibody; NHL repeat containing protein 1 antibody; NHL repeat-containing protein 1 antibody; NHL repeat-containing protein 1 gene antibody; NHLC1_HUMAN antibody; NHLRC 1 antibody; Nhlrc1 antibody
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (1-280AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:NHLRC1-Antibody-11908846.html
