PSEN1 Antibody
Produktgrößen
100 ul
£332,00
CSB-PA695720-100UL
Über dieses Produkt
- SKU:
- CSB-PA695720
- Zusätzliche Namen:
- AD3 antibody; Ad3h antibody; FAD antibody; Homo Sapiens Clone CC44 Senilin 1 antibody; Presenilin-1 CTF12 antibody; Protein S182 antibody; PS 1 antibody; PS-1 antibody; PS1-CTF12 antibody; PSEN1 antibody; PSN1_HUMAN antibody; PSNL1 antibody; S182 antibody
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376. I. Imafuku, J. Cell Biol., Oct 1999; 147: 121. Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105. Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Human presenilin 1.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:PSEN1-Antibody-11084651.html
