LIN28B Antibody
Produktgrößen
100 ul
£332,00
CSB-PA637784-100UL
Über dieses Produkt
- SKU:
- CSB-PA637784
- Zusätzliche Namen:
- CSDD 2 antibody; CSDD2 antibody; FLJ16517 antibody; Lin 28 homolog B (C. elegans) antibody; Lin 28.2 antibody; Lin-28B antibody; LIN28B antibody; LN28B_HUMAN antibody; Protein lin-28 homolog B antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma." Guo Y., Chen Y., Ito H., et al.Gene 384:51-61(2006) "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA." Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N. Mol. Cell 32:276-284(2008) "TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation." Heo I., Joo C., Kim Y.-K., Kim V.N.,et al. Cell 138:696-708(2009) "
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.242~246( P-S-V-Q-K) derived from Human LIN28B
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:LIN28B-Antibody-11083345.html
