CUL4A Antibody
Produktgrößen
50 ug
£186,00
CSB-PA619782LA01HU-50UG
100 ug
£334,00
CSB-PA619782LA01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA619782LA01HU
- Zusätzliche Namen:
- 2810470J21Rik antibody; AW495282 antibody; CUL 4A antibody; CUL-4A antibody; Cul4a antibody; Cul4a protein antibody; CUL4A_HUMAN antibody; Cullin-4A antibody; MGC36573 antibody; MGC64071 antibody
- Anwendung:
- ELISA, Immunofluorescence
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Weitere Details:
- Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Cullin-4A protein (1-61AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:CUL4A-Antibody-12554334.html
