BATF Antibody, HRP conjugated
Produktgrößen
50 ug
£186,00
CSB-PA619074LB01HU-50UG
100 ug
£334,00
CSB-PA619074LB01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA619074LB01HU
- Zusätzliche Namen:
- Activating transcription factor B antibody; B ATF antibody; B-ATF antibody; B-cell-activating transcription factor antibody; Basic leucine zipper transcription factor like antibody; Basic leucine zipper transcriptional factor ATF like antibody; Basic leucine zipper transcriptional factor ATF-like antibody; Batf antibody; BATF_HUMAN antibody; BATF1 antibody; SF HT activated gene 2 protein antibody; SF-HT-activated gene 2 protein antibody; SFA 2 antibody; SFA-2 antibody; SFA2 antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:BATF-AntibodyHRP-conjugated-11106693.html