LIN28A Antibody
Produktgrößen
100 ul
£332,00
CSB-PA586531-100UL
Über dieses Produkt
- SKU:
- CSB-PA586531
- Zusätzliche Namen:
- AL024421 antibody; CSDD1 antibody; CSDD2 antibody; FLJ12457 antibody; Lin 28 antibody; Lin 28 homolog (C. elegans) antibody; Lin 28 homolog A (C. elegans) antibody; Lin 28 homolog A antibody; Lin 28 homolog antibody; Lin-28A antibody; Lin28 antibody; Lin28, C. elegans, homolog of, A antibody; LIN28A antibody; LN28A_HUMAN antibody; Protein lin-28 homolog A antibody; Protein lin-28 homolog B antibody; RNA binding protein lin 28 antibody; Tex17 antibody; ZCCHC1 antibody; Zinc finger CCHC domain containing 1 antibody; Zinc finger CCHC domain containing protein 1 antibody; Zinc finger CCHC domain-containing protein 1 antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. Heo I., Joo C., Mol. et al., Cell 32:276-284(2008) Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009) Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009)
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:LIN28A-Antibody-11083251.html
