AXIN2 Antibody
Produktgrößen
50 ul
£186,00
CSB-PA577711-50UL
100 ul
£334,00
CSB-PA577711-100UL
Über dieses Produkt
- SKU:
- CSB-PA577711
- Zusätzliche Namen:
- Axil antibody; Axin like protein antibody; Axin-2 antibody; Axin-like protein antibody; Axin2 antibody; AXIN2_HUMAN antibody; Axis inhibition protein 2 antibody; Conductin antibody; DKFZp781B0869 antibody; MGC10366 antibody; MGC126582 antibody
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of Human AXIN2
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:AXIN2-Antibody-11100893.html
