NUPR1 Antibody, HRP conjugated
Produktgrößen
50 ug
£186,00
CSB-PA527662LB01HU-50UG
100 ug
£334,00
CSB-PA527662LB01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA527662LB01HU
- Zusätzliche Namen:
- Candidate of metastasis 1 antibody; COM1 antibody; Nuclear protein 1 antibody; Nupr1 antibody; NUPR1_HUMAN antibody; p8 protein antibody; Protein p8 antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Nuclear protein 1 protein (2-64AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:NUPR1-AntibodyHRP-conjugated-12552322.html