GFI1B Antibody
Produktgrößen
100 ul
£332,00
CSB-PA257884-100UL
Über dieses Produkt
- SKU:
- CSB-PA257884
- Zusätzliche Namen:
- GFI 1B antibody; gfi1b antibody; GFI1B protein antibody; GFI1B_HUMAN antibody; Growth factor independent 1B protein antibody; Growth factor independent 1B transcription repressor antibody; Growth factor independent protein 1B antibody; OTTHUMP00000022443 antibody; OTTHUMP00000022444 antibody; OTTHUMP000000235527 antibody; Potential regulator of CDKN1A antibody; Potential regulator of CDKN1A translocated in CML antibody; Translocated in CML antibody; Zinc finger protein Gfi-1b antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Osawa M., Yamaguchi T., Nakamura Y. Iwama A.Blood 100:2769-2777(2002) Huang D.-Y., Kuo Y.-Y., Chang Z.-F. Nucleic Acids Res. 33:5331-5342(2005) Vassen L., Fiolka K., Moeroey T. EMBO J. 25:2409-2419(2006)
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GFI1B-Antibody-11083481.html
