PTK2B (Ab-579) Antibody
Produktgrößen
100 ul
£332,00
CSB-PA213093-100UL
Über dieses Produkt
- SKU:
- CSB-PA213093
- Zusätzliche Namen:
- CADTK antibody; CAK-beta antibody; CAKB antibody; CAKbeta antibody; Calcium regulated non receptor proline rich tyrosine kinase antibody; Calcium-dependent tyrosine kinase antibody; Cell adhesion kinase beta antibody; E430023O05Rik antibody; EC 2.7.10.2 antibody; FADK 2 antibody; FADK2 antibody; FAK2 antibody; FAK2_HUMAN antibody; Focal adhesion kinase 2 antibody; MGC124628 antibody; PKB antibody; Proline-rich tyrosine kinase 2 antibody; Protein kinase B antibody; Protein Tyrosine Kinase 2 Beta antibody; Protein-tyrosine kinase 2-beta antibody; PTK antibody; PTK2B antibody; PTK2B protein tyrosine kinase 2 beta antibody; PYK2 antibody; RAFTK antibody; RAFTK2 antibody; Related adhesion focal tyrosine kinase antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca2+ levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. Lev S., Nature 376:737-745(1995). Herzog H., Genomics 32:484-486(1996). Sasaki H., J. Biol. Chem. 270:21206-21219(1995).
- Host:
- Rabbit
- Immunogen:
- Synthesized non-phosphopeptide derived from Human PYK2 around the phosphorylation site of tyrosine 579 (E-D-Y(p)-Y-K).
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:PTK2B-Ab-579-Antibody-11084439.html
