ARID1B Antibody
Produktgrößen
100 ul
£332,00
CSB-PA210417-100UL
Über dieses Produkt
- SKU:
- CSB-PA210417
- Zusätzliche Namen:
- ARID1B antibody; BAF250B antibody; DAN15 antibody; KIAA1235 antibody; OSA2AT-rich interactive domain-containing protein 1B antibody; ARID domain-containing protein 1B antibody; BRG1-associated factor 250b antibody; BAF250B antibody; BRG1-binding protein hELD/OSA1 antibody; Osa homolog 2 antibody; hOsa2 antibody; p250R antibody
- Anwendung:
- ELISA, Immunofluorescence, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity. Binds DNA non-specifically. Mungall A.J., Nature 425:805-811(2003). Mangel L., J. Biol. Chem. 273:30466-30471(1998). Imbert G., Nat. Genet. 14:285-291(1996).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from interal of Human BAF250B.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:ARID1B-Antibody-11085166.html
