BRCA1 (Ab-1423) Antibody
Produktgrößen
100 ul
£332,00
CSB-PA186422-100UL
Über dieses Produkt
- SKU:
- CSB-PA186422
- Zusätzliche Namen:
- BRCA 1 antibody; BRCA1 antibody; BRCA1 DNA repair associated antibody; BRCA1/BRCA2 containing complex subunit 1 antibody; BRCA1/BRCA2-containing complex; subunit 1 antibody; BRCA1_HUMAN antibody; BRCAI antibody; BRCC 1 antibody; BRCC1 antibody; Breast and ovarian cancer susceptibility protein 1 antibody; Breast Cancer 1 antibody; Breast Cancer 1 Early Onset antibody; Breast cancer type 1 susceptibility protein antibody; BROVCA1 antibody; FANCS antibody; IRIS antibody; PNCA4 antibody; PPP1R53 antibody; Protein phosphatase 1 regulatory subunit 53 antibody; PSCP antibody; RING finger protein 53 antibody; RNF53 antibody
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Kim ST, et al. (2002) Genes Dev; 16(5): 560-570 Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709 Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718 Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46 Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.1421~1425 (H-G-S-Q-P) derived from Human BRCA1.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:BRCA1-Ab-1423-Antibody-11083083.html
