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Antikörper

KAT5 Antibody

Produktgrößen
50 ug
£186,00
CSB-PA17849A0RB-50UG
100 ug
£334,00
CSB-PA17849A0RB-100UG
Über dieses Produkt
SKU:
CSB-PA17849A0RB
Zusätzliche Namen:
60 kDa Tat interactive protein antibody; 60 kDa Tat-interactive protein antibody; cPLA(2) interacting protein antibody; cPLA(2)-interacting protein antibody; cPLA2 antibody; cPLA2 interacting protein antibody; ESA1 antibody; Histone acetyltransferase HTATIP antibody; Histone acetyltransferase KAT5 antibody; HIV 1 Tat interactive protein antibody; HIV 1 Tat interactive protein, 60kDa antibody; HIV-1 Tat interactive protein antibody; HTATIP antibody; HTATIP1 antibody; K(lysine) acetyltransferase 5 antibody; K-acetyltransferase 5 antibody; KAT5 antibody; KAT5_HUMAN antibody; Lysine acetyltransferase 5 antibody; PLIP antibody; Tat interacting protein, 60kDa antibody; TIP antibody; Tip60 antibody
Anwendung:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Buffer:
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Klonalität:
Polyclonal
Weitere Details:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
Host:
Rabbit
Immunogen:
Recombinant Human Histone acetyltransferase KAT5 protein (3-512AA)
Isotyp:
IgG
Physischer Zustand:
Liquid
Aufreinigung:
Protein G Purified
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Hersteller:
Cusabio
Typ:
Antibody: Polyclonal Antibody
Immunofluorescent analysis of PC-3 cells using CSB-PA17849A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
IHC image of CSB-PA17849A0Rb diluted at 1:800 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA17849A0Rb diluted at 1:800 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Western Blot Positive WB detected in: HL60 whole cell lysate All lanes: KAT5 antibody at 3ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 59, 54, 62, 57 kDa Observed band size: 59 kDa