CLNS1A Antibody
Produktgrößen
100 ul
£332,00
CSB-PA159505-100UL
Über dieses Produkt
- SKU:
- CSB-PA159505
- Zusätzliche Namen:
- Chloride channel antibody; Chloride channel nucleotide sensitive 1A antibody; Chloride channel regulatory protein antibody; Chloride conductance regulator; volume sensitive antibody; Chloride conductance regulatory protein ICln antibody; Chloride ion current inducer protein antibody; ClCI antibody; CLNS 1A antibody; Clns1a antibody; CLNS1B antibody; I(Cln) antibody; ICln antibody; ICLN_HUMAN antibody; Methylosome subunit pICln antibody; nucleotide sensitive 1A antibody; Reticulocyte pICln antibody; Reticulocyte protein ICln antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996). Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995). Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from C-terminal of Human CLNS1A.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:CLNS1A-Antibody-11086369.html
