PPP4R2 Antibody
Produktgrößen
100 ul
£332,00
CSB-PA124096-100UL
Über dieses Produkt
- SKU:
- CSB-PA124096
- Zusätzliche Namen:
- BE691708 antibody; C230060M08Rik antibody; MGC131930 antibody; PP4R2 antibody; PP4R2_HUMAN antibody; PPP4R2 antibody; protein phosphatase 4, regulatory subunit 2 antibody; Serine/threonine protein phosphatase 4 regulatory subunit 2 antibody; Serine/threonine-protein phosphatase 4 regulatory subunit 2 antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Hastie C.J., Biochem. J. 347:845-855(2000). Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human PP4R2.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:PPP4R2-Antibody-11086248.html
