MERTK/TYRO3 (Ab-753) Antibody
Produktgrößen
100 ul
£332,00
CSB-PA114581-100UL
Über dieses Produkt
- SKU:
- CSB-PA114581
- Zusätzliche Namen:
- c MER antibody; c mer proto oncogene tyrosine kinase antibody; c-mer antibody; cMER antibody; cmer protooncogene tyrosine kinase antibody; Eyk antibody; MER antibody; MER receptor tyrosine kinase antibody; MERK antibody; MERPEN antibody; Mertk antibody; MERTK c-mer proto-oncogene tyrosine kinase antibody; MERTK_HUMAN antibody; MGC133349 antibody; nmf12 antibody; Nyk antibody; Proto oncogene tyrosine protein kinase MER antibody; Proto oncogene tyrosine protein kinase MER precursor antibody; Proto-oncogene c-Mer antibody; Receptor tyrosine kinase MerTK antibody; RP38 antibody; STK kinase antibody; Tyrosine-protein kinase Mer antibody
- Anwendung:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Graham D.K., Cell Growth Differ. 5:647-657(1994). Gal A., Nat. Genet. 26:270-271(2000). Ling L., J. Biol. Chem. 271:18355-18362(1996).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Internal of Human MERTK.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:MERTKTYRO3-Ab-753-Antibody-11084488.html
