GABBR1 Antibody
Produktgrößen
100 ul
£332,00
CSB-PA106396-100UL
Über dieses Produkt
- SKU:
- CSB-PA106396
- Zusätzliche Namen:
- dJ271M21.1.1 antibody; dJ271M21.1.2 antibody; FLJ92613 antibody; GABA-B receptor 1 antibody; GABA-B-R1 antibody; GABA-BR1 antibody; GABAB R1 antibody; GABAB subunit 1c antibody; GABABR1 antibody; GABBR1 3 antibody; GABBR1 antibody; GABR1_HUMAN antibody; Gamma aminobutyric acid (GABA) B receptor 1 antibody; Gamma-aminobutyric acid type B receptor subunit 1 antibody; Gb1 antibody; GPRC3A antibody; Seven transmembrane helix receptor antibody
- Anwendung:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. Xinmin Xie, J. Physiol., Jul 2006; 574: 399 - 414. A. Gambardella, Neurology, Feb 2003; 60: 560 - 563. P Tosetti, J. Physiol., Nov 2005; 568: 951 - 966. Marta Margeta-Mitrovic, PNAS, Dec 2001; 98: 14643.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Human GABA B receptor.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GABBR1-Antibody-11084552.html
