HGS Antibody
Produktgrößen
100 ul
£332,00
CSB-PA105291-100UL
Über dieses Produkt
- SKU:
- CSB-PA105291
- Zusätzliche Namen:
- Hepatocyte growth factor regulated tyrosine kinase substrate antibody; Hepatocyte growth factor-regulated tyrosine kinase substrate antibody; HGF-regulated tyrosine kinase substrate antibody; HGNC:4897 antibody; HGS antibody; HGS_HUMAN antibody; Hrs antibody; Human growth factor regulated tyrosine kinase substrate antibody; Protein pp110 antibody; ZFYVE8 antibody
- Anwendung:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Klonalität:
- Polyclonal
- Weitere Details:
- Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Asao H., J. Biol. Chem. 272:32785-32791(1997). Lu L., Gene 213:125-132(1998). Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human HGS.
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:HGS-Antibody-11084751.html
