GSK3A Antibody, HRP conjugated
Produktgrößen
50 ug
£186,00
CSB-PA05369B0RB-50UG
100 ug
£334,00
CSB-PA05369B0RB-100UG
Über dieses Produkt
- SKU:
- CSB-PA05369B0RB
- Zusätzliche Namen:
- DKFZp686D0638 antibody; Glycogen synthase kinase 3 alpha antibody; Glycogen synthase kinase-3 alpha antibody; GSK 3 alpha antibody; GSK 3A antibody; GSK-3 alpha antibody; Gsk3a antibody; GSK3A_HUMAN antibody; GSK3alpha antibody; Serine/threonine protein kinase GSK3A antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Glycogen synthase kinase-3 alpha protein (36-118AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GSK3A-AntibodyHRP-conjugated-12552027.html