KPNA5 Antibody
Produktgrößen
50 ul
£186,00
CSB-PA012487ESR2HU-50UL
100 ul
£334,00
CSB-PA012487ESR2HU-100UL
Über dieses Produkt
- SKU:
- CSB-PA012487ESR2HU
- Zusätzliche Namen:
- IMA5_HUMAN antibody; Importin alpha 6 antibody; Importin subunit alpha 6 antibody; Importin subunit alpha-6 antibody; IPOA 6 antibody; IPOA6 antibody; Karyopherin alpha 5 antibody; Karyopherin alpha 5 importin alpha 6 antibody; Karyopherin subunit alpha 5 antibody; Karyopherin subunit alpha-5 antibody; KPNA 5 antibody; KPNA5 antibody; SRP 6 antibody; SRP6 antibody
- Anwendung:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Importin subunit alpha-6 protein (1-240AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:KPNA5-Antibody-11909140.html
