PITX3 Antibody, Biotin conjugated
Produktgrößen
50 ug
£186,00
CSB-PA010844LD01HU-50UG
100 ug
£334,00
CSB-PA010844LD01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA010844LD01HU
- Zusätzliche Namen:
- Homeobox protein PITX 3 antibody; Homeobox protein PITX3 antibody; MGC12766 antibody; Paired like homeodomain transcription factor 3 antibody; Paired-like homeodomain transcription factor 3 antibody; Pituitary homeobox 3 antibody; PITX 3 antibody; Pitx3 antibody; PITX3_HUMAN antibody; PTX 3 antibody; PTX3 antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- Biotin
- Weitere Details:
- Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Pituitary homeobox 3 protein (10-200AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:PITX3-AntibodyBiotin-conjugated-12548118.html