GRK5 Antibody
Produktgrößen
50 ug
£186,00
CSB-PA009926LA01HU-50UG
100 ug
£334,00
CSB-PA009926LA01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA009926LA01HU
- Zusätzliche Namen:
- FLJ39780 antibody; FP2025 antibody; G protein coupled receptor kinase 5 antibody; G protein coupled receptor kinase GRK5 antibody; G protein-coupled receptor kinase 5 antibody; G protein-coupled receptor kinase GRK5 antibody; GPRK5 antibody; GRK-pan antibody; GRK5 antibody; GRK5_HUMAN antibody; Pan-GRK antibody
- Anwendung:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Weitere Details:
- Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human G protein-coupled receptor kinase 5 protein (406-590AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:GRK5-Antibody-12780996.html
