EFNA1 Antibody
Produktgrößen
50 ul
£186,00
CSB-PA007460ESR1HU-50UL
100 ul
£334,00
CSB-PA007460ESR1HU-100UL
Über dieses Produkt
- SKU:
- CSB-PA007460ESR1HU
- Zusätzliche Namen:
- B61 antibody; ECKLG antibody; EFL 1 antibody; EFL1 antibody; EFNA 1 antibody; Efna1 antibody; EFNA1_HUMAN antibody; EPH related receptor tyrosine kinase ligand 1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; Ephrin-A1 antibody; Ephrin-A1, secreted form antibody; EphrinA1 antibody; EPLG 1 antibody; EPLG1 antibody; Immediate early response protein B61 antibody; LERK 1 antibody; LERK-1 antibody; LERK1 antibody; Ligand of eph related kinase 1 antibody; OTTHUMP00000033242 antibody; OTTHUMP00000033271 antibody; secreted form antibody; TNF alpha-induced protein 4 antibody; TNFAIP 4 antibody; TNFAIP4 antibody; Tumor necrosis factor alpha induced protein 4 antibody; Tumor necrosis factor alpha-induced protein 4 antibody
- Anwendung:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Weitere Details:
- Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ephrin-A1 protein (19-182AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:EFNA1-Antibody-11080952.html
