DDX58 Antibody, FITC conjugated
Produktgrößen
50 ug
£186,00
CSB-PA006638LC01HU-50UG
100 ug
£334,00
CSB-PA006638LC01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA006638LC01HU
- Zusätzliche Namen:
- Ddx58 antibody; DDX58_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody; DEAD (Asp Glu Ala Asp/His) box polypeptide antibody; DEAD box protein 58 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody; DKFZp434J1111 antibody; DKFZp686N19181 antibody; FLJ13599 antibody; Probable ATP dependent RNA helicase DDX58 antibody; Probable ATP-dependent RNA helicase DDX58 antibody; Retinoic acid inducible gene 1 protein antibody; Retinoic acid-inducible gene 1 protein antibody; Retinoic acid-inducible gene I protein antibody; RIG I antibody; Rig-1 antibody; RIG-I antibody; RIG1 antibody; rigi antibody; RLR 1 antibody; RNA helicase antibody; RNA helicase RIG I antibody; SGMRT2 antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- FITC
- Weitere Details:
- nnate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Probable ATP-dependent RNA helicase DDX58 protein (1-430AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:DDX58-AntibodyFITC-conjugated-1028182.html