ASIC1 Antibody, Biotin conjugated
Produktgrößen
50 ug
£186,00
CSB-PA001142LD01HU-50UG
100 ug
£334,00
CSB-PA001142LD01HU-100UG
Über dieses Produkt
- SKU:
- CSB-PA001142LD01HU
- Zusätzliche Namen:
- ACCN2 antibody; ACCN2_HUMAN antibody; Acid sensing ion channel 1 antibody; Acid sensing ion channel 1a protein antibody; Acid sensing ion channel antibody; Acid-sensing ion channel 1 antibody; AI843610 antibody; Amiloride sensitive cation channel 2 neuronal antibody; Amiloride-sensitive cation channel 2 antibody; ASIC antibody; ASIC1 antibody; ASIC1A antibody; B530003N02Rik antibody; BNaC2 antibody; Brain sodium channel 2 antibody; Cation channel amiloride sensitive neuronal 2 antibody; hBNaC2 antibody; neuronal antibody
- Anwendung:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Klonalität:
- Polyclonal
- Konjugat:
- Biotin
- Weitere Details:
- Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Acid-sensing ion channel 1 protein (195-297AA)
- Isotyp:
- IgG
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:ASIC1-Antibody-Biotin-conjugated-12919267.html