PODXL Monoclonal Antibody
Produktgrößen
50 ul
£235,00
CSB-MA134471A0M-50UL
100 ul
£392,00
CSB-MA134471A0M-100UL
Über dieses Produkt
- SKU:
- CSB-MA134471A0M
- Zusätzliche Namen:
- Podocalyxin, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PC, PCLP-1, PODXL, PCLP, PCLP1
- Anwendung:
- ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- translate.label.attr.clone:
- 4D2G7
- Klonalität:
- Monoclonal
- Weitere Details:
- Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
- Host:
- Mouse
- Immunogen:
- Recombinant Human PODXL protein
- Isotyp:
- IgG2b
- Physischer Zustand:
- Liquid
- Aufreinigung:
- Protein G Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Cusabio
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:PODXL-Monoclonal-Antibody-1030140.html
