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Proteine und Peptide

Human Interleukin 10 (IL10), Active Protein

Produktgrößen
50 ug
£1032,00
RPU54838-50UG
100 ug
£1260,00
RPU54838-100UG
1 mg
£5241,00
RPU54838-1MG
Über dieses Produkt
SKU:
RPU54838
Zusätzliche Namen:
CSIF|Cytokine Synthesis Inhibitory Factor|IL10A|TGIF
Anwendung:
Detection/Quantitation, Tissue Culture
Buffer:
Freeze-dried powder|PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
CE/IVD:
RUO
Weitere Details:
Human Interleukin 10 (IL10), Active Protein is a purified Eukaryotic Protein.
Formulierung:
Freeze-dried powder
Immunogen:
Interleukin 10 (IL10)
Molekulargewicht:
18kDa
Physischer Zustand:
freeze-dried
Reinheit:
>97%
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C Avoid freeze/thaw cycles.
Hersteller:
Biomatik
Typ:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Catalog Protein.JPG
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4 T cell activation. Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) mediated induction of the pro-inflammatory cytokines TNFA Alpha, IL-1B Beta, IL-12, and IFNG Gamma made by cells such as macrophages and Th1 T cells. Therefore, THP1 cells were cultured in 24 well plates at a concentration of 106 cells/ml and activated by LPS (1ug/mL) in the absence or presence of IL-10 (5ng/mL, 10ng/mL) for 24h and production of IL-1B Beta was determined in the supernatants by cytokine specific ELISA. Activation of THP1 cells with LPS (1ug/mL) resulted in high levels of production of IL-1B Beta and strong inhibitory effects of IL-10 (5ng/mL, 10ng/mL) were observed on the production of IL-1B Beta as shown in Table 1.
Figure 2. SDS-PAGE