CTCF antibody - N-terminal region
Produktgrößen
25ul
£177,00
P100757-P050-25UL
100 ul
£412,00
P100757-P050-100UL
Über dieses Produkt
- SKU:
- P100757-P050
- Zusätzliche Namen:
- MRD21; FAP108; CFAP108
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site; the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element; it can block communication between enhancers and upstream promoters; thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers; prostate cancers; and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site; the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element; it can block communication between enhancers and upstream promoters; thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers; prostate cancers; and Wilms' tumors.
- Gendetails:
- CCCTC-binding factor (zinc finger protein)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human CTCF
- Molekulargewicht:
- 83kDa
- Proteindetails:
- Transcriptional repressor CTCF
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php