FEN1 Protein
Produktgrößen
5µg
£186,00
OPPA02024-5UG
Über dieses Produkt
- SKU:
- OPPA02024
- Zusätzliche Namen:
- MF1; RAD2; FEN-1
- Konzentration:
- Varies by lot. See vial for concentration.
- Weitere Details:
- FEN1 removes 5'' overhanging flaps in DNA repair and processes the 5'' ends of Okazaki fragments in lagging strand DNA synthesis. The interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate; therefore passing the substrate from one enzyme to another. FEN1 is part of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5'' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore; secondary structure can deter the protective function of this protein; leading to site-specific trinucleotide expansions.
- Molekulargewicht:
- 43 kDa
- Proteindetails:
- Flap endonuclease 1
- Reinheit:
- > 90.0% as determined by SDS-PAGE.
- Aufreinigung:
- The FEN1 protein is purified by standard chromatogrpahy techniques.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E. coli
- Lagerbedingungen:
- Store at 4°C if entire vial will be used within 2-4 weeks. Store; frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:html_datasheet.php