AURKB Protein
Produktgrößen
2µg
£186,00
OPPA01816-2UG
Über dieses Produkt
- SKU:
- OPPA01816
- Zusätzliche Namen:
- AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
- Weitere Details:
- Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores; specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation; while overexpression is seen in many kinds of cancers. AURKB phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex); which is a complex that acts as a key regulator of mitosis. High level expression of AURKB is seen in the thymus; which is also expressed in the spleen; lung; testis; colon; placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
- Molekulargewicht:
- 41.4 kDa
- Proteindetails:
- Aurora kinase B
- Reinheit:
- > 90.0% as determined by SDS-PAGE.
- Aufreinigung:
- Purified by proprietary chromatographic techniques.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E. coli
- Lagerbedingungen:
- Although stable at 4C for 1 week; should be stored below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze thaw cycles. - Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:html_datasheet.php